Nanoparticles laden in situ gel for sustained ocular drug delivery
نویسندگان
چکیده
منابع مشابه
Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery
Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC) ratios were prepared and their stability was tested in P...
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Sustained drug delivery has become the standard in modern Pharmaceutical design and an intensive research has been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in-situ forming polymeric delivery systems such as ease of administration and reduced frequency of administration, improved patient comp...
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The human nose has the potential to be an alternative route for the systemic delivery of a wide range of therapeutic agents. The richly supplied vascular nature of the nasal mucosa and its high drug permeation makes it a potential route for the administration of many drugs including proteins, peptides and vaccines. Nasal route is most suitable for those drugs which cannot be administered orally...
متن کاملDesign and optimization of novel in situ gel of mercaptopurine for sustained drug delivery
Mercaptopurine is a purine antagonist, belonging to the class of antimetabolites. Its oral absorption is erratic and variable throughout GIT, with bioavailability of 5-37% and belongs to Biopharmaceutical Classification System (BCS) class IV. The focus of the present study was to improve solubility of mercaptopurine and to release the drug uniformly throughout the GIT by formulating into a nove...
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The present work describes the formulation development of ophthalmic in situ gelling system using thermo-reversible gelling polymer, i.e. Pluronic F 127 (PF127). Because of high concentration (20 to 25%w/v) of this polymer required for in situ gelation causes irritation to the eye. So, to reduce this concentration, an attempt was made to combine the PF127 with other polymers like hydroxy propyl...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Bioallied Sciences
سال: 2013
ISSN: 0975-7406
DOI: 10.4103/0975-7406.111824